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Beta blockers with CYP2D6 polymorphic metabolism

"I Met Tim Carver, the metabolic polymorph":
· The following beta blockers require dose adjustment due to CYP2D6 polymorphic metabolism:
Metoprolol
Timolol
Carvedilol
(in patients with lower or higher than normal CYP2D6 activity)
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---David Shprecher Lake Erie College of Osteopathic Medicine

Therapeutic index: formula

TILE:
TI = LD50 / ED50
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---Robert O'Connor University College Dublin

Cancer drugs: time of action between DNA->mRNA

ABCDEF:
Alkylating agents
Bleomycin
Cisplastin
Dactinomycin/ Doxorubicin
Etoposide
Flutamide and other steroids or their antagonists (eg tamoxifen, leuprolide)
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---Sung Hoon Kim El Paso, TX

Busulfan: features

ABCDEF:
Alkylating agent
Bone marrow suppression s/e
CML indication
Dark skin (hyperpigmentation) s/e
Endrocrine insufficiency (adrenal) s/e
Fibrosis (pulmonary) s/e
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---Sung Hoon Kim El Paso, TX

Torsades de Pointes: drugs causing

APACHE:
Amiodarone
Procainamide
Arsenium
Cisapride
Haloperidol
Eritromycin
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---Flavio Nacul Federal University of Rio de Janeiro

Morphine: side-effects

MORPHINE:
Myosis
Out of it (sedation)
Respiratory depression
Pneumonia (aspiration)
Hypotension
Infrequency (constipation, urinary retention)
Nausea
Emesis
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---Tony Duffy Medical Student Glasgow

Microtubules: drugs that act on microtubules.

"The MicroTubule Growth Voiding Chemicals":
Thiabendazole
Mebendazole
Taxol
Griseofulvin
Vincristine/ Vinblastine
Colchicine
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---Javaid H. Wani, Ph.D. Spartan University School of Medicine

Aminoglycosides: common characteristics

AMINO:
Active Against Aerobic gram negative
Mechanism of resistance are Modifying enzymes
Inhibit protein synthesis by binding to 30S subunit
Nephrotoxic
Ototoxic
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---David H. Chafey Ponce School of Medicine

Sulfonamides: common characteristics

SULFA:
Steven-Johnson syndrome/ Skin rash / Solubility low
Urine precipitation/ Useful for UTI
Large spectrum (gram positives and negatives)
Folic acids synthesis blocker (as well as synthesis of nucleic acids)
Analog of PABA
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---David H. Chafey Ponce School of Medicine

Medication administration: short checklist

TRAMP:
· Before dispensing medication, ensure have correct:
Time
Route
Amount
Medication
Patient
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---Lori Registered Nurse